Problem with SendMail Jobs

Hello,

we have recently started running version 8.1.5 in our production environment.
We have made the following observation in the area of sending mails, that they sometimes run on the following errors.

2022-08-02 07:13:59 +02:00 - \<queue1> - VI.JobService.JobComponents.MailComponent - 2290ca32-de67-460f-b344-c2ff312ee873: Errors occurred
[MailKit.Net.Smtp.SmtpCommandException] 4.4.1 Connection timed out. Total session duration: 00:10:23.5469954
at StdioProcessor.StdioProcessor._Execute(Job job)
at VI.JobService.JobComponents.MailComponent.Activate(String task)
at VI.JobService.JobComponents.MailComponent._SendRichMail()
at VI.JobService.JobComponents.MailComponent._Send(MimeMessage message, MailSecurity security)
at MailKit.MailTransport.Send(MimeMessage message, CancellationToken cancellationToken, ITransferProgress progress)
at MailKit.Net.Smtp.SmtpClient.Send(FormatOptions options, MimeMessage message, CancellationToken cancellationToken, ITransferProgress progress)
at MailKit.Net.Smtp.SmtpClient.Send(FormatOptions options, MimeMessage message, MailboxAddress sender, IList`1 recipients, CancellationToken cancellationToken, ITransferProgress progress)
at MailKit.Net.Smtp.SmtpClient.FlushCommandQueue(MimeMessage message, MailboxAddress sender, IList`1 recipients, CancellationToken cancellationToken)
at MailKit.Net.Smtp.SmtpClient.ProcessMailFromResponse(MimeMessage message, MailboxAddress mailbox, SmtpResponse response)

2022-08-02 07:14:05 +02:00 - \<queue1> - VI.JobService.JobComponents.MailComponent - 2faedfc9-2fd2-4b7f-8125-53cd08ee350c: Errors occurred
[MailKit.ServiceNotConnectedException] The SmtpClient is not connected.
at StdioProcessor.StdioProcessor._Execute(Job job)
at VI.JobService.JobComponents.MailComponent.Activate(String task)
at VI.JobService.JobComponents.MailComponent._SendRichMail()
at VI.JobService.JobComponents.MailComponent._Send(MimeMessage message, MailSecurity security)
at MailKit.MailTransport.Send(MimeMessage message, CancellationToken cancellationToken, ITransferProgress progress)
at MailKit.Net.Smtp.SmtpClient.Send(FormatOptions options, MimeMessage message, CancellationToken cancellationToken, ITransferProgress progress)
at MailKit.Net.Smtp.SmtpClient.Send(FormatOptions options, MimeMessage message, MailboxAddress sender, IList`1 recipients, CancellationToken cancellationToken, ITransferProgress progress)

So far, we have not been able to identify a pattern. The colleagues who administrate our Exchange environment can't see any abnormalities on their servers.

What could be causing these error messages?

Thank you very much for any information that could help us to find a solution.