Will this authentication scenario work?

I'm trying to get Active Directory SSO working for the Web Portal.

Domain A

Application Server

Job Server

Workstation Server

Domain B

Web Portal hosted

There's no trust between Domain A and Domain B. Domain B gets synced to in Identity Manager so it has a Domain record in the ADS section of Manager. I've added Domain B to the TargetSystem\ADS\AuthenticationDomains config parameter. Users log into Domain B with Domain B credentials, the Windows Auth seems to be working with anon turned off. The result I'm getting is that in the Application Server in Domain A I get a message in the app log.

VI.Base.VIException: Failed to authenticate user. ---> VI.Base.ViException: The current user could not be determined.

Is there anyway to get this authentication method going?